Visualization of three pathways for macromolecule transport across cultured endothelium and their modification by flow (vol 313, pg H959, 2017)

2020

Abstract

The lines in Fig. 11 were given the wrong sign and should have been flipped vertically, as shown in the revised figure below.Hence, the conclusion that cells align so as to minimize transWSS under these conditions is incorrect.(The cells do not align with the mean WSS vector either.)The conclusion that paracellular permeability correlates best with the magnitude of the minimized transverse WSS still stands because neither the data in Fig. 7, A and B, nor the statistics in DISCUSSION, paragraph 13, have changed as a result of the error.We speculate that some feature of the cell other than its long axis or its nucleus aligns so as to minimize transverse WSS, detects the resulting magnitude, and affects paracellular permeability.